Is There a Better Technique to Wash Sperm For IUI (Intra Uterine Insemination) or IVF? The Answer Ma

Only 5% of the volume of the “raw” ejaculate is composed of sperm. The remainder comes from secretions made by the prostate, seminal vesicles and cowpers glands. Those secretions enable sperm to survive until they can travel into the cervical crypts, then into the uterus and into the fallopian tube to fertilize an egg. For purposes of IUI (or IVF) sperm must be separated from the raw ejaculate. Most commonly a technique called a gradient wash is used which involves layering semen on top of a higher density solution and then centrifuging the combination, pulling the sperm down to the bottom while leaving the rest of the raw ejaculate behind.

Increased “DNA fragmentation” within sperm has been associated with lower pregnancy and higher miscarriage rates in a variety of publications. A recent poster presented at the ASRM (American Society of Reproductive Medicine) Meeting in Denver this past week (October 2018) demonstrated that processing sperm using the Zymot microfluidics chip, when compared to using a gradient wash resulted in sperm with significantly lower DNA fragmentation.

The paper submitted by Chinnasamy et al from UCSF and Stanford University compared results of 62 “split” semen specimens. Findings showed that use fo the Zymot device resulted in specimens with lower DNA Fragmentation (as measured by TUNEL assay) compared to both centrifuged specimens and to sperm from the raw ejaculate.

As to conclusions regarding improved pregnancy results, results are still pending. There is controversy as to the clinical utility of DNA fragmentation; however, it is hoped that this technology may serve to improve results of fertility treatment now and in the future.

You Might Also Enjoy...

What Causes Blockage in the Reproductive System?

Are you struggling with infertility? For couples affected by male infertility, reproductive system blockage is often to blame. Learn more about the male reproductive system, common causes of blockage, and what you can do to improve your fertility.

The Link Between Obesity and ED

Obesity is a major health issue for American men. It increases your risk of serious conditions like heart disease and diabetes — and it also affects your sex life. Obesity is linked to erectile dysfunction, and now’s the time to learn more.

Seven Symptoms of Kidney Stones

Kidney stones are common, but varying sizes and shapes mean symptoms aren’t always the same. Learn to recognize the most common symptoms of kidney stones, from lower back pain to foul-smelling urine, so you can get the treatment you need.

Men Suffer From Hormone Imbalance Too

Hormone imbalance is often labeled as a women’s health issue. While it’s true that hormonal changes in menopause trigger notorious symptoms, men are at risk for hormone imbalance too. Learn more about low testosterone and how it can be treated.

What Is a Varicocele?

A varicocele is an enlarged vein in your scrotum, and it’s a leading cause of male infertility. Learn the signs and symptoms of varicoceles and what your treatment options are here.