Is There a Better Technique to Wash Sperm For IUI (Intra Uterine Insemination) or IVF? The Answer Ma

Only 5% of the volume of the “raw” ejaculate is composed of sperm. The remainder comes from secretions made by the prostate, seminal vesicles and cowpers glands. Those secretions enable sperm to survive until they can travel into the cervical crypts, then into the uterus and into the fallopian tube to fertilize an egg. For purposes of IUI (or IVF) sperm must be separated from the raw ejaculate. Most commonly a technique called a gradient wash is used which involves layering semen on top of a higher density solution and then centrifuging the combination, pulling the sperm down to the bottom while leaving the rest of the raw ejaculate behind.

Increased “DNA fragmentation” within sperm has been associated with lower pregnancy and higher miscarriage rates in a variety of publications. A recent poster presented at the ASRM (American Society of Reproductive Medicine) Meeting in Denver this past week (October 2018) demonstrated that processing sperm using the Zymot microfluidics chip, when compared to using a gradient wash resulted in sperm with significantly lower DNA fragmentation.

The paper submitted by Chinnasamy et al from UCSF and Stanford University compared results of 62 “split” semen specimens. Findings showed that use fo the Zymot device resulted in specimens with lower DNA Fragmentation (as measured by TUNEL assay) compared to both centrifuged specimens and to sperm from the raw ejaculate.

As to conclusions regarding improved pregnancy results, results are still pending. There is controversy as to the clinical utility of DNA fragmentation; however, it is hoped that this technology may serve to improve results of fertility treatment now and in the future.

You Might Also Enjoy...

When Should Prostate Cancer be Treated?

Getting a prostate cancer diagnosis is scary, especially since it’s the second leading cause of death among American men. But did you know that it doesn’t always require intervention? Read on to learn how to know when you may need treatment.

Recognizing the Symptoms of Varicoceles

Varicoceles affect approximately 15% of adult men and nearly 20% of adolescents. While varicoceles aren’t dangerous, they can lead to fertility problems. Here’s how to recognize the signs of this common issue and to see if you’re at risk.

4 Tips for Preventing Kidney Stones

Kidney stones are a reminder that even a relatively tiny medical abnormality can cause great pain. You can’t always prevent them, but you can take practical and simple steps to significantly reduce your risks of developing kidney stones.

What is the Success Rate for a Vasectomy Reversal?

So, since having a vasectomy, you’ve changed your mind and now want to have children? You’re not alone. Many men have their vasectomy reversed. Your success rate depends on many factors, none greater than the skill level of your surgeon. .